The literature shows an association between inflammatory bowel disease IBD and decreased bone mineral density in the adult population ie IBD and osteoporosis, but not studied while the risk of fractures. This meta-analysis is to study IBD and osteoporotic fractures.
Hildalgo and colleague researchers conducted a meta-analysis of seven observational studies (five cohort, one case-control and one cross-sectional) identified through a literature search on the MEDLINE and EMBASE databases
Hidalgo DF, Boonpheng B, Phemister J, Hidaldo J, Young M. Inflammatory Bowel Disease and Risk of Osteoporotic Fractures: A Meta-Analysis. Cureus. 2019 Sep 30
The overall analysis showed a 32 per cent higher risk for osteoporotic fractures in patients with IBD, either ulcerative colitis or Crohn’s disease, than the control individuals who did not have IBD (OR, 1.32; 95% CI, 1.20-1.45; P<.001). Heterogeneity among the included studies was low (I2=42.3). In a sensitivity analysis, the results remained unaffected by the inclusion of data on children. Corticosteroid use as a confounding variable was adjusted using direct standardisation.
A significant association between IBD and the risk of developing osteoporotic fractures was observed in this study. There is a 32% increased risk, which is consistent with different cohort studies previously done.